As a new anti-cancer drug ‘FCIC-15’ enters clinical practice, it is determined that the drug requires hepatic activation in order to elicit a therapeutic effect

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As a new anti-cancer drug ‘FCIC-15’ enters clinical practice, it is determined that the drug requires hepatic activation in order to elicit a therapeutic effect

As a new anti-cancer drug ‘FCIC-15’ enters clinical practice, it is determined that the drug requires hepatic activation in order to elicit a therapeutic effect. Further studies identify that the sole enzyme involved in the activation of this drug is CYP2C19. a) Select ONE specific factor (from the categories environmental, genetic or physiological) that may contribute to inter-individual variability in the activation of ‘FCIC-15’, and explain the potential consequences of this variability in terms of treatment response and tolerability. Briefly discuss how this variability may be controlled for in a clinical setting.

As a new anti-cancer drug ‘FCIC-15’ enters clinical practice, it is determined that the drug requires hepatic activation in order to elicit a therapeutic effect. Further studies identify that the sole enzyme involved in the activation of this drug is CYP2C19.
a) Select ONE specific factor (from the categories environmental, genetic or physiological) that may contribute to inter-individual variability in the activation of ‘FCIC-15’, and explain the potential consequences of this variability in terms of treatment response and tolerability.
Briefly discuss how this variability may be controlled for in a clinical setting.


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